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Anti-NGAL antibody (Capture Ab)

Catalog #BDA1006
Size1 mg
Price---
In stockYes
Datasheet MSDS

Overview


Catalog# BDA1006


Lot # Check on the product label


Size 1mg


Isotype IgG1  


Clone # F2


Host Mouse


Reactivity
Human


Product Form Liquid


Purification & Buffer
Protein A or G purified and supplied in 0.01 M PBS (pH7.4) without preservative.


Purity >95% by HPLC & SDS-PAGE


Concentration 4 mg/ml


Immunogen
Recombinant human NGAL.


Specificity It specifically recognize the human NGAL.


Recommend Application
Western Blot
ELISA
Lateral flow
Other applications have not been tested.
The optimal dilutions should be determined by end user.


Matched antibody pair
Capture Ab: NGAL mAb (clone # F2)
Detection Ab: NGAL mAb (clone # 1G2)


Storage Instruction
Aliquot and store at -20°C for long term (at least one year).
Avoid repeated freeze and thaw cycles.


Background

Lipocalin-2 (LCN2), also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), is a protein associated with neutrophil gelatinase. The 25-kD LCN2 protein is believed to bind small lipophilic substances such as bacteria-derived lipopolysaccharide (LPS) and formylpeptides and may function as a modulator of inflammation. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of lipocalin-2. Secreted lipocalin-2 then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 also functions as a growth factor.


Reference

1.    Kjeldsen, L., Johnsen, A. H., Sengelov, H., Borregaard, N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J. Biol. Chem. 268: 10425-10432, 1993.
2.    Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem A (December 2004). "Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron". Nature 432 (7019): 917–21.
3.    Schmidt-Ott KM, Mori K, Li JY, Kalandadze A, Cohen DJ, Devarajan P, Barasch J (February 2007). "Dual action of neutrophil gelatinase-associated lipocalin". J. Am. Soc. Nephrol. 18 (2): 407–13.
 

Gene Information


OMIM: 600181

Swiss Port: P80188
Gene ID: 3934