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PRODUCTS
Anti- Alpha-Actin (cardiac muscle) antibody
Overview
Catalog# BPA1002Lot # Check on the product label
Size 100μg
Isotype IgG
Host Rabbit
Reactivity
Human, mouse, rat
Product Form Liquid
Purification Immunogen affinity purified
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to the N-terminal of Alpha-Actin.
Recommend Application
Western Blot, WB (1:200-500)
Other applications have not been tested.
The optimal dilutions should be determined by end user.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.
Storage Instruction
Store at 4°C after thawing (1 week). Aliquot and store at -20°C for long term (at least one year).
Avoid repeated freeze and thaw cycles.
Background
Actin, alpha, skeletal muscle 1 (ACTA1) gene encodes skeletal muscle alpha-actin, which is the predominant actin isoform in the sarcomeric thin filaments of adult skeletal muscle, and essential, along with myosin, for muscle contraction.1 Actin alpha 1 which is expressed in skeletal muscle is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.2 Alpha-skeletal actin can activate a regulatory pathway linking a subset of muscle genes that operates independently of normal differentiation and withdrawal from the cell cycle.3
Actin, alpha, skeletal muscle 1 (ACTA1) gene encodes skeletal muscle alpha-actin, which is the predominant actin isoform in the sarcomeric thin filaments of adult skeletal muscle, and essential, along with myosin, for muscle contraction.1 Actin alpha 1 which is expressed in skeletal muscle is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.2 Alpha-skeletal actin can activate a regulatory pathway linking a subset of muscle genes that operates independently of normal differentiation and withdrawal from the cell cycle.3
Reference
1. Laing, N. G., Dye, D. E., Wallgren-Pettersson, C., Richard, G., Monnier, N., Lillis, S., Winder, T. L., Lochmuller, H., Graziano, C., Mitrani-Rosenbaum, S., Twomey, D., Sparrow, J. C., Beggs, A. H., Nowak, K. J. Mutations and polymorphisms of the skeletal muscle alpha-actin gene (ACTA1). Hum. Mutat. 30: 1267-1277, 2009.
2. "Entrez Gene: ACTA1 actin, alpha 1, skeletal muscle".
3. Gunning, PW; Ferguson, V; Brennan, KJ; Hardeman, EC (2001). "Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle.". Journal of cell science 114 (Pt 3): 513–24.
1. Laing, N. G., Dye, D. E., Wallgren-Pettersson, C., Richard, G., Monnier, N., Lillis, S., Winder, T. L., Lochmuller, H., Graziano, C., Mitrani-Rosenbaum, S., Twomey, D., Sparrow, J. C., Beggs, A. H., Nowak, K. J. Mutations and polymorphisms of the skeletal muscle alpha-actin gene (ACTA1). Hum. Mutat. 30: 1267-1277, 2009.
2. "Entrez Gene: ACTA1 actin, alpha 1, skeletal muscle".
3. Gunning, PW; Ferguson, V; Brennan, KJ; Hardeman, EC (2001). "Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle.". Journal of cell science 114 (Pt 3): 513–24.
Gene Information
OMIM: 102540
Swiss Port: P68032
Gene ID: 70
