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Anti- Alpha-Actin (cardiac muscle) antibody

Catalog #BPA1002
Size100 ug/100 ul
In stockYes
Datasheet MSDS


Catalog#  BPA1002

Lot # Check on the product label

Size 100μg

Isotype IgG

Host Rabbit

Human, mouse, rat

Product Form Liquid

Purification Immunogen affinity purified

A synthetic peptide (conjugated with KLH) corresponding to the N-terminal of Alpha-Actin.

Recommend Application
Western Blot, WB (1:200-500)
Other applications have not been tested.
 The optimal dilutions should be determined       by end user.

Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.

Storage Instruction 
Store at 4°C after thawing (1 week). Aliquot and store at -20°C for long term (at least one year).
Avoid repeated freeze and thaw cycles.

Actin, alpha, skeletal muscle 1 (ACTA1) gene encodes skeletal muscle alpha-actin, which is the predominant actin isoform in the sarcomeric thin filaments of adult skeletal muscle, and essential, along with myosin, for muscle contraction.1 Actin alpha 1 which is expressed in skeletal muscle is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.2 Alpha-skeletal actin can activate a regulatory pathway linking a subset of muscle genes that operates independently of normal differentiation and withdrawal from the cell cycle.3

1. Laing, N. G., Dye, D. E., Wallgren-Pettersson, C., Richard, G., Monnier, N., Lillis, S., Winder, T. L., Lochmuller, H., Graziano, C., Mitrani-Rosenbaum, S., Twomey, D., Sparrow, J. C., Beggs, A. H., Nowak, K. J. Mutations and polymorphisms of the skeletal muscle alpha-actin gene (ACTA1). Hum. Mutat. 30: 1267-1277, 2009.
2. "Entrez Gene: ACTA1 actin, alpha 1, skeletal muscle".
3. Gunning, PW; Ferguson, V; Brennan, KJ; Hardeman, EC (2001). "Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle.". Journal of cell science 114 (Pt 3): 513–24. 

Gene Information

OMIM: 102540
Swiss Port: P68032
Gene ID: 70