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Anti- alpha 1-antitrypsin, A1AT antibody

Catalog #BPA1003
Size100 ug/100 ul
In stockYes
Datasheet MSDS


Catalog#  BPA1003

Lot # Check on the product label

Size 100 μg

Isotype IgG

Host Rabbit


Product Form Liquid

Purification Immunogen affinity purified

A synthetic peptide (conjugated to KLH) corresponding to the region of human alpha 1-antitrypsin.

Recommend Application
Western Blot, WB (1:500)
Other applications have not been tested.
 The optimal dilutions should be determined       by end user.

Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage Instruction 
Store at 4°C after thawing (1 week). Aliquot and store at -20°C for long term (at least one year).
Avoid repeated freeze and thaw cycles.

alpha 1-antitrypsin(A1AT) is a protease inhibitor belonging to the serpin superfamily. [1] It is generally known as serum trypsin inhibitor. A1AT is a 52-kDa serpin with a characteristic secondary structure of beta sheets and alpha helices. Disorders of this protein include alpha 1-antitrypsin deficiency, causes the degradation especially of lung tissue, and eventually leads to characteristic manifestations of pulmonary emphysema. [2] As A1AT is expressed in the liver, certain mutations in the gene encoding the protein can cause misfolding and impaired secretion, which can lead to liver cirrhosis.

1. Gettins PG (2002). "Serpin structure, mechanism, and function". Chem Rev 102 (12): 4751–804.
2. DeMeo DL, Silverman EK (2004). "α1-Antitrypsin deficiency · 2: Genetic aspects of α1-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema risk". Thorax 59 (3): 259–64.