Overview

Catalog# BTL1033

Lot # Check on the product label

Size 100μg

Isotype IgG

Host Rabbit

Reactivity
Human, mouse

Product Form Liquid (2mg/ml)

Immunogen
With a synthetic peptide corresponding to residues of human H3.1(NP_003520.1).

Recommend Application
Western Blot (1:5000-20000)
 Other applications have not been tested.
 The optimal dilutions should be determined       by end user.

Storage Instruction

Store at -20°C for 1 year.
Avoid repeated freeze and thaw cycles.

Background
Histone H3.1 is a protein that in humans is encoded by the HIST1H3C gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes.

Reference
1. Kardalinou E, Eick S, Albig W, Doenecke D (Dec 1993). "Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones". J Cell Biochem 52 (4): 375–83.
2. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22.
3. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98.