Polyclonal Anti- Vitamin K-dependent protein C Antibody

Catalog#  BPA1109

Lot # Check on the product label

Size 100 μg

Isotype IgG

Host Rabbit

Reactivity Human

Product Form Liquid

Purification Immunogen affinity purified

Immunogen 

A synthetic peptide (conjugated with KLH) corresponding to the region of human Vitamin K-dependent protein C.

Recommend Application

Western Blot, WB (1:500)

Other applications have not been tested.

The optimal dilutions should be determined by end user.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.

Storage Instruction 

Store at 4°C after thawing (1 week). Aliquot and store at -20°C for long term (at least one year).

Avoid repeated freeze and thaw cycles.

Background

Vitamin K-dependent protein C, also called Protein C(PROC), is a vitamin K-dependent plasma glycoprotein. The PROC gene contains 9 exons and spans about 11 kb. Protein C synthesis occurs in the liver, it is a major component in anticoagulation in the human body. Activated protein C(APC) has been studied as way of treating lung injury, also has been considered for use in improving patient outcome in cases of ischemic stroke, a medical emergency in which arterial blockage deprives a region of brain of oxygen, causing tissue death. 

Reference

1. Plutzky, J., Hoskins, J. A., Long, G. L., Crabtree, G. R. Evolution and organization of the human protein C gene. Proc. Nat. Acad. Sci. 83: 546-550, 1986.

1. Mosnier LO, Zlokovic BV, Griffin JH (April 2007). "The cytoprotective protein C pathway". Blood 109 (8): 3161–72.