Monoclonal Anti- Human Serum Albumin Antibody

Catalog# BMA1024

Lot # Check on the product label

Size 100 μg

Isotype IgG1

Clone # H6

Host Mouse

Reactivity Human

Product Form Liquid

Purification Protein A purified

Immunogen Purified human serum albumin.

Recommend Application

Western Blot,WB (1:1000)

Other applications have not been tested.

The optimal dilutions should be determined by end user.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.

Storage Instruction 

Store at 4°C after thawing (1 week). Aliquot and store at -20°C for long term (at least one year).

Avoid repeated freeze and thaw cycles.

Background

Human serum albumin is the most abundant protein in human blood plasma. It is produced in the liver, and cleaved in the Golgi vesicles. It has a molecular mass of 67 kDa. Albumin transports hormones, fatty acids, and other compounds, buffers pH, and maintains osmotic pressure. As a negative acute-phase protein, is down-regulated in inflammatory states. As such, it is not a valid marker of nutritional status; rather, it is a marker in inflammatory states. Human albumin is often used to replace lost fluid and help restore blood volume in trauma, burns and surgery patients.

Reference

1. Masaki T, Matsuura T, Ohkawa K, Miyamura T, Okazaki I, Watanabe T, Suzuki T (July 2006). "All-trans retinoic acid down-regulates human albumin gene expression through the induction of C/EBPβ-LIP". Biochem. J. 397 (2): 345–53.

2. The Albumin Reviewers (Alderson P, Bunn F, Li Wan Po A, Li L, Pearson M, Roberts I, Schierhout G). Human albumin solution for resuscitation and volume expansion in critically ill patients. Cochrane Database of Systematic Reviews 2004, Issue 4. Art. No.: CD001208.