Monoclonal Anti- Junctophilin-2, JPH-2 Antibody

Catalog# BMA1026

Lot # Check on the product label

Size 100 μg

Isotype IgG1

Clone # D5-3

Host Mouse

Reactivity Human, mouse, rat

Product Form Liquid

Purification Protein A purified

Immunogen 

A synthetic peptide (conjugated with KLH) corresponding to the region of human JPH-2.

Recommend Application

Western Blot,WB (1:200-500)

Immunohistochemistry, IHC-P (1:50)

Immunocytochemistry, ICC (1:20-50)

Other applications have not been tested.

The optimal dilutions should be determined by end user.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.

Storage Instruction 

Store at 4°C after thawing (1 week). Aliquot and store at -20°C for long term (at least one year).

Avoid repeated freeze and thaw cycles.

Background

Junctophilin 2, also known as JPH2, is a member of the junctophilin gene family (the other members of the family are JPH1, JPH3, and JPH4), located between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR). It is the predominant isoform in cardiac tissue, and also expressed with JPH1 in skeletal muscle. JPH2 has been shown to be downregulated in several animal models of heart failure.

Reference

1. Garbino A, van Oort RJ, et al. (2009). "Molecular evolution of the junctophilin gene family.". Physiol Genomics 37 (3): 175–86.