C-Peptide Protein (Active)

Catalog# BRP1003

Lot # Check on the product label

Size 100 μg

Description

Recombinant full length human C-Peptide protein.

Synonyms C-peptide, Connecting peptide

Source E. coli

Purity >95% by HPLC & SDS-PAGE

Formulation  Liquid

Concentration 1 mg/ml

Application

ELISA

Other applications have not been tested.

The optimal dilutions should be determined by end user.

Storage buffer

Each vial contains 10mM PBS (pH7.5) without preservative.

Storage & Expiration

Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term.

Avoid repeated freeze and thaw cycles.

Background

Connecting peptide, or C-peptide, is a short 31-amino-acid protein that connects insulin's A-chain to its B-chain in the proinsulin molecule. C-peptide has been shown to bind to the surface of a number of cell types such as neuronal, endothelial, fibroblast and renal tubular, at nanomolar concentrations to a receptor that is likely G-protein-coupled. It has been found to exert beneficial effects in many tissues affected by diabetic microvascular complications, including the kidneys. C-peptide at physiological concentrations effectively reduces diabetes-induced glomerular hyperfiltration via constriction of the afferent arteriole, dilation of the efferent arteriole, and inhibition of tubular reabsorption in experimental models of type 1 diabetes.

Reference

1. Nordquist L, Wahren J (2009). "C-Peptide: the missing link in diabetic nephropathy". Rev Diabet Stud 6 (3): 203–10.