D-dimer Protein (Active)

Catalog# BNP1013

Lot # Check on the product label

Size 1 mg

Description

Purified human D-dimer protein.

Source Human tissue

Formulation Liquid

Application

ELISA

Other applications have not been tested.

Storage buffer

Each vial contains 10 mMPBS (pH7.4).

Storage & Expiration

Ship at 2-8°C. Upon receipt, aliquot and store at 2-8°C for one year.

Avoid repeated freeze and thaw cycles.

Background

D-dimer is a fibrin degradation product (or FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it contains two crosslinked D fragments of the fibrin protein. The D-dimer antigen is a unique marker of fibrin degradation that is formed by the sequential action of 3 enzymes: thrombin, factor XIIIa, and plasmin. Its concentration may be determined by a blood test to help diagnose thrombosis. Since its introduction in the 1990s, it has become an important test performed in patients suspected of thrombotic disorders. While a negative result practically rules out thrombosis, a positive result can indicate thrombosis but does not rule out other potential causes. Its main use, therefore, is to exclude thromboembolic disease where the probability is low. In addition, it is used in the diagnosis of the blood disorder disseminated intravascular coagulation.

Reference

1. Adam SS, Key NS, Greenberg CS (March 2009). "D-dimer antigen: current concepts and future prospects". Blood 113 (13): 2878–2887.