HCG beta Protein (Active)

Catalog# BNP1018

Lot # Check on the product label

Size 500 μg

Description

Purified human HCG beta protein.

Synonyms Chorionic gonadotropin beta subunit, hCG-b, β-HCG

Source Human pregnancy urine

Formulation Liquid

Concentration 1 mg/ml

Purity ≧90% by SDS-PAGE

Application

ELISA

Other applications have not been tested.

Storage buffer

Each vial contains 0.01 M PBS, 0.15 M NaCl (pH 7.4) with 0.05% NaN_3.

Storage & Expiration

Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term.

Avoid repeated freeze and thaw cycles.

Background

Human chorionic gonadotropin (CG) is a glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. It is a glycoprotein composed of 237 amino acids with a molecular mass of 25.7 kDa. It is heterodimeric, with an α (alpha) subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and β (beta) subunit that is unique to hCG. β subunit is secreted by some cancers including seminoma, choriocarcinoma, germ cell tumors, hydatidiform mole formation, teratoma with elements of choriocarcinoma, and islet cell tumor. Combined with alpha-fetoprotein, β-HCG is an excellent tumor marker for the monitoring of germ cell tumors.

Reference

1. Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW (June 1994). "Crystal structure of human chorionic gonadotropin". Nature 369 (6480): 455–61.