Monoclonal Anti- Muellerian-inhibiting factor, AMH (Detection Ab) Antibody

Catalog# BDA1049

Lot # Check on the product label

Size 1 mg

Isotype IgG1

Clone # 2D3

Host Mouse

Reactivity Human

Product Form Liquid

Purification & Buffer

Protein A or G purified and supplied in 0.9% NaCl without preservative.

Purity >95% by HPLC & SDS-PAGE

Immunogen Recombinant protein. 

Recommend Application

ELISA

Lateral flow assay (rapid test)

Other applications have not been tested.

The optimal dilutions should be determined by end user.

Matched antibody pair

Capture Ab: AMH mAb (clone # B9)

Detection Ab: AMH mAb (clone # 2D3)

Storage Instruction 

Aliquot and store at 2-8°C for long term (at least one year).

Avoid repeated freeze and thaw cycles.

Background

Anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting hormone (MIH), is a glycoprotein hormone structurally related to inhibin and activin from the transforming growth factor beta superfamily, whose key roles are in growth differentiation and folliculogenesis. In humans, it is encoded by the AMH gene, on chromosome 19p13.3, while its receptor is encoded by the AMHR2 gene on chromosome 12. AMH is activated by SOX9 in the Sertoli cells of the male fetus. Its expression inhibits the development of the female reproductive tract, or Müllerian ducts (paramesonephric ducts), in the male embryo, thereby arresting the development of fallopian tubes, uterus, and upper vagina.

Reference

1. Rzeszowska M, Leszcz A, Putowski L, Hałabiś M, Tkaczuk-Włach J, Kotarski J, Polak G (2016). "Anti-Müllerian hormone: structure, properties and appliance". Ginekologia Polska. 87 (9): 669–674.

2. Cate RL, Mattaliano RJ, Hession C, Tizard R, Farber NM, Cheung A, et al. (June 1986). "Isolation of the bovine and human genes for Müllerian inhibiting substance and expression of the human gene in animal cells". Cell. 45 (5): 685–698.

3. Imbeaud S, Faure E, Lamarre I, Mattéi MG, di Clemente N, Tizard R, et al. (December 1995). "Insensitivity to anti-müllerian hormone due to a mutation in the human anti-müllerian hormone receptor". Nature Genetics. 11 (4): 382–388.