Monoclonal Anti- Sulfamerazine / Sulfaguanidine Antibody

Catalog# BDA1019

Lot # Check on the product label

Size 1mg

Host Mouse

Product Form Liquid

Concentration 8 mg/ml (Changed for different lots)

Purification & Buffer

Protein A or G purified and supplied in 0.01 M PBS (pH7.4)

Purity >95% by HPLC & SDS-PAGE

IC50 Value

0.6-1.0 ppb

Sensitivity 4 ppb

Recommend Application

ELISA (1:100000)

Other applications have not been tested.

The optimal dilutions should be determined by end user.

Storage Instruction 

Aliquot and store at -20°C for 2 years. 

Avoid repeated freeze and thaw cycles.

Background

Aloisio C et al investigated the effect on solubility and release of ternary complexes of sulfamerazine (SMR) with β-(βCD), methyl-(MβCD) and hydroxypropyl-β-cyclodextrin (HPβCD) using meglumine (MEG) as the ternary component. Solid state analysis was performed using Fourier-transform infrared spectroscopy (FT IR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD), which demonstrated that different interactions occurred among SMR, MEG and MβCD or HPβCD in the ternary lyophilized systems. The ternary complexes with βCD and MβCD produced an additional retention effect on the release of SMR compared to the corresponding binary complexes, implying that they were clearly superior in terms of solubility and release modulation.

Reference

1. Aloisio C, de Oliveira AG, Longhi M. Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine. J Pharm Biomed Anal. 2014 Nov;100:64-73.