Polyclonal Anti- Proteolipid protein 2, PLP2 antibody

Catalog#  YPA2548

Lot # Check on the product label

Size 100 μl

Isotype IgG

Host Rabbit

Reactivity 

Human

Immunogen Recombinant human PLP2 protein expressed in E.Coli.

Purification Immunogen affinity purified

Content In 0.01M PBS (pH7.4), 0.5% BSA, 30% Glycerol and 0.05% Sodium Azide.

Recommend Application

Western Blot, WB (1:250-1000)

ELISA (1:50-500)

Immunohistochemistry, IHC-P (1:20-200)

Flow Cytometry, Flow-Cyt (1:20-100)

Other applications have not been tested.

The optimal dilutions should be determined by end user.

Storage Instruction 

Ship at 2-8°C, when receipt, aliquot and store at -20°C for one year.

Avoid repeated freeze and thaw cycles.

Background

Proteolipid protein 2 is a protein that in humans is encoded by the PLP2 gene. This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5.

Reference

1. Fisher, S. E., Ciccodicola, A., Tanaka, K., Curci, A., Desicato, S., D'Urso, M., Craig, I. W. Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp. Genomics 45: 340-347, 1997.

2. Oliva, M. M., Wu, T. C., Yang, V. W. Isolation and characterization of a differentiation-dependent gene in the human colonic cell line HT29-18. Arch. Biochem. Biophys. 302: 183-192, 1993.

3. Zhang, L., Jie, C., Obie, C., Abidi, F., Schwartz, C. E., Stevenson, R. E., Valle, D., Wang, T. X chromosome cDNA microarray screening identifies a functional PLP2 promoter polymorphism enriched in patients with X-linked mental retardation. Genome Res. 17: 641-648, 2007.