Polyclonal Anti- Histone H3.1 Antibody

Catalog# BTL1032

Lot # Check on the product label

Size 100μg

Host Rabbit

Reactivity

Human, mouse, rat, monkey, Chinese hamster

Specificity

Detect the endogenous levels of total Histone H3.1.

Product Form Liquid

Immunogen 

A synthetic peptide corresponding to residues of human Histone H3.1.

Recommend Application

Western Blot (1:5000-20000)

Other applications have not been tested.

The optimal dilutions should be determined by end user.

Storage Instruction 

Store at -20°C for 1 year.

Avoid repeated freeze and thaw cycles.

Background

Histone H3.1 is a protein that in humans is encoded by the HIST1H3C gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes.

Reference

1. Kardalinou E, Eick S, Albig W, Doenecke D (Dec 1993). "Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones". J Cell Biochem 52 (4): 375–83.

2. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22.

3. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98.