Recombinant Rabbit Monoclonal Anti- TPX2 antibody
|
Catalog# |
BRM1120-2 |
|---|---|
|
Lot # |
Check on the product label |
|
Size |
100 μl |
| Isotype |
IgG |
| Host | Rabbit |
|
Reactivity |
Human, mouse, rat |
| Immunogen | Recombinant protein of human TPX2. |
|
Clone ID |
6F6 |
| Synonyms | C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, REPP86, p100, microtubule nucleation factor, TPX2 microtubule nucleation factor |
| Content | Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA. |
| Recommend Application |
Western Blot, WB (1:1000) The optimal dilutions should be determined by end user. |
| Storage Instruction | Ship at 2-8°C, when receipt, aliquot and store at -20°C for one year. Avoid repeated freeze and thaw cycles. |
|
Background |
Targeting protein for Xklp2 is a protein that in humans is encoded by the TPX2 gene. It is one of the many spindle assembly factors that play a key role in inducing microtubule assembly and growth during M phase. TPX2 has been reported to have two NLS-containing domains that mediate its localization to microtubules; one in the amino-terminal domain, and the other in the carboxy-terminal domain.[8][9] In addition to an NLS, the carboxy-terminal domain of TPX2 consists of tandem repeats that cover over two-thirds of the protein and are computationally predicted to consist of predominantly alpha-helical content. |
|
Reference |
1. Sanchez-Pulido L, Perez L, Kuhn S, Vernos I, Andrade-Navarro MA (October 2016). "The C-terminal domain of TPX2 is made of alpha-helical tandem repeats". BMC Structural Biology. 16 (1): 17. 2. Alfaro-Aco R, Thawani A, Petry S (April 2017). "Structural analysis of the role of TPX2 in branching microtubule nucleation". The Journal of Cell Biology. 216 (4): 983–997. |
