Recombinant Rabbit Monoclonal Anti- SCD1 antibody
|
Catalog# |
BRM1126-1 |
|---|---|
|
Lot # |
Check on the product label |
|
Size |
50 μl |
| Isotype |
IgG |
| Host | Rabbit |
|
Reactivity |
Human, mouse, rat |
| Immunogen | Recombinant protein of human SCD1. |
|
Clone ID |
2W1 |
| Synonyms | FADS5; Acyl-CoA desaturase; Delta(9)-desaturase; Stearoyl-CoA desaturase; Fatty acid desaturase. |
| Content | Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA. |
| Recommend Application | Western Blot, WB (1:1000) Immunohistochemistry,IHC-P (1:200-2000) Immunocytochemistry, ICC/IF (1:100) Immunoprecipitation, IP (1:20-50) Flow Cytometry, Flow-Cyt (1:200) Other applications have not been tested. The optimal dilutions should be determined by end user. |
| Storage Instruction | Ship at 2-8°C, when receipt, aliquot and store at -20°C for one year. Avoid repeated freeze and thaw cycles. |
|
Background |
Stearoyl-CoA desaturase (Δ-9-desaturase or SCD-1) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the formation of monounsaturated fatty acids (MUFAs), specifically oleate and palmitoleate from stearoyl-CoA and palmitoyl-CoA. Oleate and palmitoleate are major components of membrane phospholipids, cholesterol esters and alkyl-diacylglycerol. In humans, the enzyme is present in two isoforms, encoded respectively by the SCD1 and SCD5 genes. Stearoyl-CoA desaturase-1 is a key enzyme in fatty acid metabolism. It is responsible for forming a double bond in stearoyl-CoA. This is how the monounsaturated fatty acid oleic acid is produced from the saturated fatty acid, stearic acid. |
|
Reference |
1. Paton CM, Ntambi JM (2017-03-08). "Biochemical and physiological function of stearoyl-CoA desaturase". American Journal of Physiology. Endocrinology and Metabolism. 297 (1): E28 – E37. |
