Recombinant Rabbit Monoclonal Anti- Paxillin antibody
|
Catalog# |
BRM1130-1 |
|---|---|
|
Lot # |
Check on the product label |
|
Size |
50 μl |
| Isotype |
IgG |
| Host | Rabbit |
|
Reactivity |
Human, mouse |
| Immunogen | A synthetic peptide of human Paxillin. |
|
Clone ID |
6Q1 |
| Synonyms | Paired box protein Pax 1; PAX 1; PAX1; Paxillin alpha; PXN |
| Content | Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA. |
| Recommend Application |
Western Blot, WB (1:1000) The optimal dilutions should be determined by end user. |
| Storage Instruction | Ship at 2-8°C, when receipt, aliquot and store at -20°C for one year. Avoid repeated freeze and thaw cycles. |
|
Background |
Paxillin is a protein that in humans is encoded by the PXN gene. Paxillin is expressed at focal adhesions of non-striated cells and at costameres of striated muscle cells, and it functions to adhere cells to the extracellular matrix. Mutations in PXN as well as abnormal expression of paxillin protein has been implicated in the progression of various cancers. Human paxillin is 64.5 kDa in molecular weight and 591 amino acids in length. The C-terminal region of paxillin is composed of four tandem double zinc finger LIM domains that are cysteine/histidine-rich with conserved repeats; these serve as binding sites for the protein tyrosine phosphatase-PEST, tubulin and serves as the targeting motif for focal adhesions. |
|
Reference |
1."Protein sequence of human PXN (Uniprot ID: P49023)". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Archived from the original on July 13, 2015. Retrieved July 13, 2015. |
