Recombinant Rabbit Monoclonal Anti- Cyclin T1 antibody
|
Catalog# |
BRM1137-2 |
|---|---|
|
Lot # |
Check on the product label |
|
Size |
100 μl |
| Isotype |
IgG |
| Host | Rabbit |
|
Reactivity |
Human, mouse, rat |
| Immunogen | Recombinant protein of human Cyclin T1. |
|
Clone ID |
2A7 |
| Synonyms | CCNT1; CCNT; CYCT1; HIVE1 |
| Content | Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA. |
| Recommend Application |
Western Blot, WB (1:1000) The optimal dilutions should be determined by end user. |
| Storage Instruction | Ship at 2-8°C, when receipt, aliquot and store at -20°C for one year. Avoid repeated freeze and thaw cycles. |
|
Background |
Cyclin-T1 is a protein that in humans is encoded by the CCNT1 gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Positive transcriptional elongation factor b (P-TEFb) contains the catalytic subunit cyclin-dependent kinase 9 (Cdk9) and the regulatory subunit cyclin T. Cyclin T1 and Cdk9 are the key factors of the PTEFb pathways and are overexpressed in the human head and neck carcinoma cell line. Positive expression of cyclin T1 was a good prognostic factor in patients with gastric GISTs. The high expression of cyclin T1 is a favorable prognostic factor in treating patients with stomach adenocarcinoma. |
|
Reference |
1. Lin LF, Jin JS, Chen JC, Huang CC, Sheu JH, Chen W, Tsao TY, Hsu CW. Positive cyclin T expression as a favorable prognostic factor in treating gastric gastrointestinal stromal tumors. Mol Clin Oncol. 2016 Jun;4(6):971-975. |
