Recombinant Human IL-13 Protein

Check on the product label

50 μg

Recombinant human IL-13 is produced by the mammalian system, with the target gene encoding Gly35-Asn146 expressed with 6x His-tag at the C-terminus.

IL13, IL-13, P600, interleukin 13

Human Cells

AAH96139

>95% by SDS-PAGE

<0.01 EU/µg by LAL test

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Dissolve the lyophilized protein in distilled water (It is not recommended to reconstitute to a concentration <100 μg/ml.)

SDS-PAGE

Other applications have not been tested.

The optimal dilutions should be determined by end user.

Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term.

Avoid repeated freeze and thaw cycles.

Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with a length of 1.4kb. It has a mass of 13 kDa and folds into 4 alpha helical bundles. The secondary structural features of IL-13 are similar to that of Interleukin 4 (IL-4); however it only has 25% sequence identity to IL-4 and is capable of IL-4 independent signaling. IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, eosinophils and nuocytes. Interleukin-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis and chitinase up-regulation. It is a mediator of allergic inflammation and different diseases including asthma, and atopic dermatitis.

1. Minty A, Chalon P, Derocq JM, Dumont X, Guillemot JC, Kaghad M, et al. (March 1993). "Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses". Nature. 362 (6417): 248–250.

2. McKenzie AN, Culpepper JA, de Waal Malefyt R, Brière F, Punnonen J, Aversa G, et al. (April 1993). "Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function". Proceedings of the National Academy of Sciences of the United States of America. 90 (8): 3735–3739.