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Catalog# |
BRP1197-1 |
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Lot # |
Check on the product label |
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Size |
10 μg |
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Description |
Recombinant mouse IL-23 is produced by the mammalian system, with the target gene encoding Val22-Ala196& Met23-Ser335 expressed. |
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Synonyms |
IL 23, IL 23 A, IL 23 subunit alpha, IL 23A, IL 23p19, IL23A, IL-23A, IL23P19, Interleukin 23 subunit alpha, Interleukin 23 subunit p19, P19, SGRF |
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Source |
Human Cells |
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Uniprot No. |
Q9EQ14&P43432 |
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Purity |
>95% by SDS-PAGE |
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Endotoxin level |
<1 EU/µg by LAL test |
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Formulation |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
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Reconstitution |
Dissolve the lyophilized protein in distilled water (It is not recommended to reconstitute to a concentration <100 μg/ml.) |
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Application |
SDS-PAGE Other applications have not been tested. The optimal dilutions should be determined by end user. |
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Storage& Expiration |
Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles. |
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Background |
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit. IL-23 is part of the IL-12 family of cytokines. The functional receptor for IL-23 (the IL-23 receptor) consists of a heterodimer between IL-12Rβ1 and IL-23R. IL-23 was discovered in the year 2000 by Robert Kastelein and colleagues at the DNAX research institute using a combination of computational, biochemical and cellular immunology approaches. |
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Reference |
1. Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, et al. (November 2000). "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12". Immunity. 13 (5): 715–25. 2. Cauli A, Piga M, Floris A, Mathieu A (2015-10-01). "Current perspective on the role of the interleukin-23/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis)". ImmunoTargets and Therapy. 4: 185–90. 3. Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, et al. (June 2002). "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R". Journal of Immunology. 168 (11): 5699–708. |
