Monoclonal Anti- Complement C3-β chain antibody

Catalog# BMA1013

Lot # Check on the product label

Size 100 μg

Isotype IgG2b

Clone # S8-6

Host Mouse

Reactivity Human

Product Form Liquid

Purification Protein A purified

Immunogen 

A synthetic peptide (conjugated with KLH) corresponding to the region of human Complement C3-β chain.

Recommend Application

Western Blot, WB (1:1000)

Other applications have not been tested.

The optimal dilutions should be determined by end user.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.

Storage Instruction 

Store at 4°C after thawing (1 week). Aliquot and store at -20°C for long term (at least one year).

Avoid repeated freeze and thaw cycles.

Background

Complement component 3, often simply called C3, is a member of the complement system. The complement system is an important mediator of natural and acquired immunity. It consists of approximately 30 proteins that can exhibit catalytic activity, function as regulators, or act as cellular surface receptors. These components normally circulate in inactive forms and are activated by the classical, alternative, or lectin pathways. Complement component 3 plays a central role in all 3 activation pathways. People with C3 deficiency are susceptible to bacterial infection. Clinically, the Level of C3 in the blood may be measured to support or refute a particular medical diagnosis. For example, low C3 levels are associated with some types of kidney disease such as post-infectious glomerulonephritis and shunt nephritis.

Reference

1. Reis, E. S., Falcao, D. A., Isaac, L. Clinical aspects and molecular basis of primary deficiencies of complement component C3 and its regulatory proteins factor I and factor H. Scand. J. Immunol. 63: 155-168, 2006.

2. Lachmann P (December 1975). "Genetics of the complement system". J. Med. Genet. 12 (4): 372–7.

3. Matsuyama W, Nakagawa M, Takashima H, Muranaga F, Sano Y, Osame M (December 2001). "Molecular analysis of hereditary deficiency of the third component of complement (C3) in two sisters". Intern. Med. 40 (12): 1254–8.