Monoclonal Anti- LAG1 longevity assurance homolog 2, LASS2 Antibody

Catalog# BMA1028

Lot # Check on the product label

Size 100 μg

Isotype IgG2b

Clone # N39

Host Mouse

Reactivity Human

Product Form Liquid

Purification Protein A purified

Immunogen 

A synthetic peptide (conjugated with KLH) corresponding to the extracellular region of human LASS2 .

Recommend Application

Western Blot,WB (1:200-1:500)

Other applications have not been tested.

The optimal dilutions should be determined by end user.

Storage Buffer

In TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.

Storage Instruction 

Store at 4°C after thawing (1 week). Aliquot and store at -20°C for long term (at least one year).

Avoid repeated freeze and thaw cycles.

Background

Lass2 (LAG1 longevity assurance homolog 2) is a protein that in humans is encoded by the LASS2 gene. It has sequence similarity to yeast longevity assurance gene 1. And it is highly expressed in liver and kidney, which is very different from the expression of the previously identified human LAG1 homologue LAG1Hs-1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. LASS2 protein was able to inhibit the colony formation of human hepatoma cells in vitro, and it also plays a role in the regulation of cell growth.

Reference

1. Pan H, Qin WX, Huo KK, Wan DF, Yu Y, Xu ZG, Hu QD, Gu KT, Zhou XM, Jiang HQ, Zhang PP, Huang Y, Li YY, Gu JR (Sep 2001). "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1". Genomics 77 (1–2): 58–64.