Recombinant Human Thyroid stimulating hormone receptor 420, TSHR420 Protein

Catalog# BRP1124

Lot # Check on the product label

Size 1 mg

Description

Recombinant human TSHR420 protein with his tag.

Synonyms Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R, TSHR (200-420 aa), LGR3

Source E. Coli

Purity >90% by SDS-PAGE

Formulation Liquid

Application

ELISA

SDS-PAGE

Other applications have not been tested.

The optimal dilutions should be determined by end user.

Storage buffer

Each vial contains 20mM Tris-HCl (pH8.0).

Storage & Expiration

Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term.

Avoid repeated freeze and thaw cycles.

Background

Thyroid stimulating hormone receptor (TSHR), also known as Thyrotropin receptor is a member of the leucine-rich repeat-containing G protein-coupled receptors. G protein-coupled receptors (GPCRs) are the largest family of plasma membrane receptors. They mediate the effects of several endogenous cues and serve as important pharmacological targets. TSHR is primarily found on the surface of the thyroid epithelial cells. Both TSHR and its ligand TSH have evolved to acquire specificity, minimize cross-reaction to other glycoprotein hormone receptors, and modulate cognate interaction (and thereby thyrotropic activity).

Reference

1. Farid NR, Szkudlinski MW (2004). "Minireview: structural and functional evolution of the thyrotropin receptor". Endocrinology 145 (9): 4048–57.