Recombinant Human Thyroid stimulating hormone receptor 420, TSHR420 Protein
Lot # Check on the product label
Size: 1 mg
Description: Recombinant human TSHR420 protein with his tag.
Synonyms: Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R, TSHR (200-420 aa), LGR3
Source: E. Coli
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Price: $1200.00
Catalog# BRP1124
Lot # Check on the product label
Size 1 mg
Description
Recombinant human TSHR420 protein with his tag.
Synonyms Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R, TSHR (200-420 aa), LGR3
Source E. Coli
Purity >90% by SDS-PAGE
Formulation Liquid
Application
ELISA
SDS-PAGE
Other applications have not been tested.
The optimal dilutions should be determined by end user.
Storage buffer
Each vial contains 20mM Tris-HCl (pH8.0).
Storage & Expiration
Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term.
Avoid repeated freeze and thaw cycles.
Background
Thyroid stimulating hormone receptor (TSHR), also known as Thyrotropin receptor is a member of the leucine-rich repeat-containing G protein-coupled receptors. G protein-coupled receptors (GPCRs) are the largest family of plasma membrane receptors. They mediate the effects of several endogenous cues and serve as important pharmacological targets. TSHR is primarily found on the surface of the thyroid epithelial cells. Both TSHR and its ligand TSH have evolved to acquire specificity, minimize cross-reaction to other glycoprotein hormone receptors, and modulate cognate interaction (and thereby thyrotropic activity).
Reference
1. Farid NR, Szkudlinski MW (2004). "Minireview: structural and functional evolution of the thyrotropin receptor". Endocrinology 145 (9): 4048–57.