Recombinant Human Thyroid peroxidase, TPO Protein

Catalog# BRP1125

Lot # Check on the product label

Size 100 μg

Description

Recombinant human TPO protein.

Synonyms Thyroid peroxidase, TPO, thyroperoxidase, iodide peroxidase

Source E. Coli

Purity >90% by SDS-PAGE

Formulation Liquid

Application

ELISA

SDS-PAGE

Other applications have not been tested.

The optimal dilutions should be determined by end user.

Storage buffer

Each vial contains 20mM Tris-HCl (pH8.0).

Storage & Expiration

Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term.

Avoid repeated freeze and thaw cycles.

Background

Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase, is an enzyme expressed mainly in the thyroid where it is secreted into colloid. In humans, thyroperoxidase is encoded by the TPO gene. Thyroid peroxidase (TPO) deficiency, caused by biallelic TPO mutations, is a well-established genetic form of congenital hypothyroidism (CH). TPO mutations with residual activity are associated with mild TPO deficiency, which is clinically characterized by marked goiter, mild TSH elevation, high serum T₃ to T₄ molar ratio, and high serum thyroglobulin levels.

Reference

1. Narumi S, Fox LA, Fukudome K, Sakaguchi Z, Sugisawa C, Abe K, Kameyama K, Hasegawa T. Narumi S, Fox LA, Fukudome K, Sakaguchi Z, Sugisawa C, Abe K, Kameyama K, Hasegawa T. Endocr J. 2017 Sep 1.