Recombinant Human Thyroid peroxidase, TPO Protein
Lot # Check on the product label
Size: 100 μg
Description: Recombinant human TPO protein.
Synonyms: Thyroid peroxidase, TPO, thyroperoxidase, iodide peroxidase
Source: E. Coli
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Price: $300.00
Catalog# BRP1125
Lot # Check on the product label
Size 100 μg
Description
Recombinant human TPO protein.
Synonyms Thyroid peroxidase, TPO, thyroperoxidase, iodide peroxidase
Source E. Coli
Purity >90% by SDS-PAGE
Formulation Liquid
Application
ELISA
SDS-PAGE
Other applications have not been tested.
The optimal dilutions should be determined by end user.
Storage buffer
Each vial contains 20mM Tris-HCl (pH8.0).
Storage & Expiration
Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term.
Avoid repeated freeze and thaw cycles.
Background
Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase, is an enzyme expressed mainly in the thyroid where it is secreted into colloid. In humans, thyroperoxidase is encoded by the TPO gene. Thyroid peroxidase (TPO) deficiency, caused by biallelic TPO mutations, is a well-established genetic form of congenital hypothyroidism (CH). TPO mutations with residual activity are associated with mild TPO deficiency, which is clinically characterized by marked goiter, mild TSH elevation, high serum T3 to T4 molar ratio, and high serum thyroglobulin levels.
Reference
1. Narumi S, Fox LA, Fukudome K, Sakaguchi Z, Sugisawa C, Abe K, Kameyama K, Hasegawa T. Narumi S, Fox LA, Fukudome K, Sakaguchi Z, Sugisawa C, Abe K, Kameyama K, Hasegawa T. Endocr J. 2017 Sep 1.