Monoclonal Anti- Cortisol Antibody

Catalog# BDA1023

Lot # Check on the product label

Size 1 mg

Host Mouse

Product Form Liquid

Purification & Buffer

Protein A or G purified and supplied in 0.01 M PBS (pH7.2)

Purity >95% by HPLC & SDS-PAGE

IC50 Value 0.2 ppb

Molecular weight 155 kDa

Specificity

10% cross-reactivity with Fludrocortisone, 6.7% cross-reactivity with Dexamethasone

Recommend Application

ELISA 

Western Blot, WB

Other applications have not been tested.

The optimal dilutions should be determined by end user.

Storage Instruction 

Aliquot and store at -20°C for 2 years. 

Avoid repeated freeze and thaw cycles.

Background

Cortisol, known more formally as Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal cortex. It is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism. It plays an important role in glycogenolysis, the breaking down of glycogen to glucose-1-phosphate and glucose, in liver and muscle tissue. It also decreases bone formation. Various synthetic forms of cortisol are used to treat a variety of diseases.

Reference

1. Scott E (2011-09-22). "Cortisol and Stress: How to Stay Healthy". About.com. Retrieved 2011-11-29.

2. Hoehn K, Marieb EN (2010). Human Anatomy & Physiology. San Francisco: Benjamin Cummings.