Monoclonal Anti- Ochratoxin A Antibody

Catalog# BDA1022

Lot # Check on the product label

Size 1mg

Host Mouse

Product Form Liquid

Concentration 8.1 mg/ml

Purification & Buffer

Protein A or G purified and supplied in 0.01 M PBS (pH7.4)

Purity >95% by HPLC & SDS-PAGE

IC50 Value

0.6-1.5 ppb

Sensitivity 0.2 ppb

Recommend Application

ELISA (1:100000)

Other applications have not been tested.

The optimal dilutions should be determined by end user.

Storage Instruction 

Aliquot and store at -20°C for 2 years. 

Avoid repeated freeze and thaw cycles.

Background

Ochratoxins are a group of mycotoxins produced by some Aspergillus species and some Penicillium species, especially P. verrucosum and P. carbonarius. Ochratoxin A is the most prevalent and relevant fungal toxin of this group, while ochratoxins B and C are of lesser importance. Ochratoxin A (OTA), a toxin produced by several species of Aspergillus and Penicillium, is one of the most abundant food-contaminating mycotoxins. There were high levels of OTA contaminations in wheat in the areas with high incidence of esophageal cancer in north China. This finding suggests that exposure to low levels of OTA may be a critical etiological factor for esophageal cancer in these areas. It could induce DNA damage, G2 arrest and apoptosis in Het-1A cells, which may be involved in the esophageal toxicity of OTA. OTA in red chili peppers may be associated with the development of gallbladder cancer.

Reference

1. Liu J, Wu S, Shen H, Cui J, Wang Y, Xing L, Wang J, Yan X, Zhang X. Ochratoxin A induces DNA damage and G2 phase arrest in human esophageal epithelium Het-1A cells in vitro. J Toxicol Sci. 2015;40(5):657-65.

2. Ikoma T, Tsuchiya Y, Asai T, Okano K, Ito N, Endoh K, Yamamoto M, Nakamura K. Ochratoxin A Contamination of Red Chili Peppers from Chile, Bolivia and Peru, Countries with a High Incidence of Gallbladder Cancer. Asian Pac J Cancer Prev. 2015;16(14):5987-91.