FGF acidic / FGF1 Protein (Active)
Lot # Check on the product label
Size: 100 μg
Description: Recombinant human FGF acidic / FGF1 protein with molecular weight 15.3kDa.
Synonyms: Fibroblast growth factor 1, FGF1, Acidic fibroblast growth factor, aFGF, Endothelial cell growth factor, ECGF, Heparin-binding growth factor 1, HBGF-1, FGFA
Source: E. Coli
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Price: $330.00
Catalog# BRP1018
Lot # Check on the product label
Size 100 μg
Description
Recombinant human FGF acidic / FGF1 protein with molecular weight 15.3kDa.
Synonyms Fibroblast growth factor 1, FGF1, Acidic fibroblast growth factor, aFGF, Endothelial cell growth factor, ECGF, Heparin-binding growth factor 1, HBGF-1, FGFA
Source E. Coli
Purity >95% by SDS-PAGE
Formulation Lyophilized
Reconstitution
Reconstitute with sterile 18MΩ-cm H2O.
Endotoxin level < 0.1 ng/μg (1 EU/μg) by LAL test
Dimers < 1% by SDS-PAGE
Storage buffer
Each vial contains 10 mM Phosphate buffer and 200 mM NaCl (pH7.0) without preservatives.
Storage & Expiration
Ship at 4℃. Upon receipt, store at -20℃ or -80℃ for long term. After reconstituting, it can store at 4℃ for a week, it is recommended to add 0.1% HSA or BSA for long term.
Avoid repeated freeze and thaw cycles.
Background
Fibroblast growth factor, acidic (FGFA) also know as Fibroblast growth factor 1 (FGF1) is expressed in the proliferative and hypertrophic zones of human cartilage. It is the prototype of the 22-member FGF family of proteins and has been implicated in a range of physiological processes, including development, wound healing and cardiovascular changes. The intracellular mammalian FGF1 was phosphorylated on a single phosphorylation site (ser130), and that phosphorylation occurred in the nucleus following activation and nuclear import of protein kinase C-delta (PRKCD). Phosphorylated FGF1 was then exported to the cytosol via exportin-1 (XPO1).
Reference
1. Theil, E. (1987). "Ferritin: structure, gene regulation, and cellular function in animals, plants, and microorganisms.". Annual review of biochemistry 56 (1): 289–315.
2. Pham, C. G., Bubici, C., Zazzeroni, F., Papa, S., Jones, J., Alvarez, K., Jayawardena, S., De Smaele, E., Cong, R., Beaumont, C., Torti, F. M., Torti, S. V., Franzoso, G. Ferritin heavy chain upregulation by NF-kappa-B inhibits TNF-alpha-induced apoptosis by suppressing reactive oxygen species. Cell 119: 529-542, 2004.
